URINARY OUTPUT OF ADRENALINE, NORADRENALINE, AND 3-METHOXY-4-HYDROXYMANDELIC ACID FOLLOWING CENTRIFUGATION AND ANTICIPATION OF CENTRIFUGATION *
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چکیده
منابع مشابه
Determination of 3-methoxy-4-hydroxymandelic acid in urine.
Five different methods for the determination of 3-methoxy-4-hydroxymandelic acid (vanilmandelic acid, VMA) in urine were compared: a GLC-FID catecholamine metabolite profiling method, an HPLC method with electrochemical detection, the method of Pisano et al. [1962) Clin. Chim. Acta 7, 285-291), a one dimensional paper chromatographic method with diazotized p-nitroaniline staining and the commer...
متن کاملDetermination of urinary 3-methoxy-4-hydroxymandelic acid (vanillylmandelic acid) by paper electrophoresis.
called vanillylmandelic acid (VMA), in urine has recently come into use as a confirmatory test for pheochromocytoma (1-6). Armstrong and his associates (1, 2, 7) discovered that this phenolic acid occurred in small amounts in normal human urine and in elevated concentrations in pheochromocytoma. As a result of their observations (1, 2) and especially of those by others in related investigations...
متن کامل3-methoxy-4-hydroxymandelic acid (vma) by microfiber chromatography.
A method is presented for the rapid, precise, quantitative measurement of 3-methoxy4-hydroxymandelic acid (VMA) in urine. The method is unique in that it utilizes silica-gel-impregnated glass fiber as a support medium for thin-layer chromatography. An ethyl acetate extract of acidified urine was spotted and chromatographed in an ascending technic using tolulene, glacial acetic acid, and ethyl a...
متن کاملThe diagnosis of pheochromocytoma by determination of urinary 3-methoxy-4-hydroxymandelic acid.
In 1957, Armstrong, McMillan and Shaw demonstrated a metabolite of epinephrine (E) and norepinephrine (NE) in normal human urine (2, 3). This substance, 3-methoxy,4-hydroxymandelic acid (VMA, for vanillylmandelic acid), was excreted in abnormally large amounts in three patients with pheochromocytomas (3). Recent studies of sympathomimetic amine metabolism (Figure 1) (4-7) suggested that the uri...
متن کاملUrinary excretion of 3-methoxy-4-hydroxymandelic acid and 3-methoxy-4-hydroxyphenylacetic acid by 288 patients with neuroblastoma and related neural crest tumors.
The catecholamine metabolites 3-methoxy-4-hydroxyman delic acid (VMA) and 3-methoxy-4-hydroxyphenylacetic acid (HVA) were assayed in initialurine specimensof 288 patients with neuroblastoma and related tumors of neural crest origin (NCT). The interrelationships between the excretion of these metabolites, age at diagnosis, stage of the disease, site of the primary tumor, and prognosis were exami...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1960
ISSN: 0021-9738
DOI: 10.1172/jci104173